HerbGoldenseal
Limited human evidence supports goldenseal's efficacy for most promoted uses; animal and in vitro studies suggest antimicrobial, anti-inflammatory, and potential cardiovascular effects, but human data are lacking.
Benefits
- Traditionally used for digestive support
- skin and eye irritations
- antimicrobial
- anti-inflammatory
- and antioxidant properties observed in lab and animal studies.
Key compounds
BerberineHydrastineCanadinePalmatineCanadalineCanadinic acidQuinic acid esters
May help with
- Native Americans historically used goldenseal for digestive disorders
- wounds
- skin and eye conditions
- as a bitter tonic
- and as a yellow dye.
Best for these goals
Traditionally used for digestive supportskin and eye irritationsantimicrobialanti-inflammatoryand antioxidant properties observed in lab and animal studies.
How to use it
Gargle, Loose, Mouthwash, Powder, Liquid extract, Dietary supplement
Evidence level
Limited
Cautions & interactions
Avoid during pregnancy and breastfeeding due to berberine's harm to newborns; potential for toxicity with long-term use; possible carcinogenicity in rodents; risk of microbial contamination in some products. | Interactions: May alter metabolism of many medications, including metformin and those processed by CYP450 enzymes; consult healthcare provider before use.
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